The liver is the largest and most important metabolic organ in the human body and is responsible for many functions related to maintaining internal homeostasis. The liver consists of several types of cells, including hepatocytes, cholangiocytes, hepatic stellate cells, Kupffer cells, and liver sinusoidal endothelial cells.
Reprogramming of mouse and human somatic cells into highly proliferative iPSCs was first achieved by nuclear transfer of combinations of transcription factors, including Oct3/4, SOX2, c-Myc, and Klf4 or Oct4, SOX2, NANOG, and LIN28 into dermal fibroblasts. iPSCs possess ESC properties, with similar cardiac potential, while circumventing ethical objections against embryonic harvesting and bypassing the problem of immune rejection. Various techniques have now been developed to generate iPSC–CMs.
Most of the diseases for which clinical benefit from MSCs has been reported are diseases for which there are currently no specific treatments with desirable outcomes.
Dental-derived MSCs exhibit the same properties as bone marrow-derived MSCs (BM-MSCs); moreover, they possess immunomodulatory and anti-inflammatory benefits in the local dental tissue environment.
Reconstruction of severe periodontal defects, such as damage to the alveolar bone or soft periodontal tissue, remains a complex and challenging field for clinicians.
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For immediate consultation with experts from the I.D. Institute for Stem Cell and Gene Research
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A medical journal published by the I.D. Institute for Stem Cell and Genome Research
A medical journal published by the I.D. Institute for Stem Cell and Genome Research
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Join the I.D. Community, an interactive environment bringing together experts, alumni, and students. This community aims to:
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Discuss Cutting-edge Research: Explore contemporary debates such as Digital Twins, Gerontology, and AI in medicine.
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