Since the discovery of spindle-shaped bone marrow-derived plastic adherent cells in the mid-1970s, science has come a long way, and studies have found that these cells can differentiate into osteoblasts and chondrocytes.
Stem cells (SCs) hold great promise in cell therapy, tissue engineering, and regenerative medicine as well as pharmaceutical and biotechnological applications.
They have the ability to self-renew and the ability to differentiate into specialized cell types depending on the source of isolation. However, the use of SCs for clinical applications requires high quality and quantity of cells.
Retinal damage caused by ischemia, infection, or physical injury results in the degeneration or death of photoreceptor cells, as well as severe vision loss. No effective neuroprotective drugs are available in the clinic to restore damaged cells. Our research group has shown that intravenous transplantation of MSCs was effective in alleviating photoreceptor damage.