Immune immunotherapy has improved, with immune checkpoint inhibitors (ICIs) being the most effective. Antitumor responses mediated by ICIs generally depend on T cells capable of recognizing different types of cells.
Nucleotide biosynthesis inhibitors were among the first antitumor agents to be discovered, and they remain the backbone of treatment for many cancer indications. Recently, nucleotide biosynthesis has been “rediscovered” several times as a critical vulnerability of cancer in various genomic screening approaches.