Aging skin is closely associated with an undesirable aesthetic appearance, caused by loss of function and structural degeneration of the skin. This can lead to more serious complications, including increased susceptibility to diseases such as eczema, dermatitis, autoimmune disorders, and skin cancer. Additionally, aging skin exhibits increased oxidative activity and increased production of matrix metalloproteases (MMPs), which are typically involved in matrix degradation. Furthermore, exposure to ultraviolet radiation is known to promote premature skin aging, i.e., photoaging. Therefore, rejuvenation treatments that focus on preventing and reversing skin aging are in high demand in our society, which increasingly aims to maintain a youthful appearance and improve their health.
