Medical Articles

The ovarian reserve is the fundamental component that determines female fertility. It consists of immature germ cells trapped within the primordial follicles.

Infertility is a global health challenge affecting approximately 15% of couples. Assisted reproductive technologies such as ICSI and IVF have improved the chances of pregnancy for some couples, but there are several limitations to the success of these techniques, especially in advanced cases or those related to egg and sperm quality and endometrial function. Success rates also decline with age due to diminished ovarian reserve or damage to the uterine lining.

In recent years, the term "tissue-engineered ovary" has become a prominent topic in experimental research in reproductive and regenerative medicine. These innovations rely on a combination of pluripotent stem cells and three-dimensional tissue engineering techniques, raising a profound scientific question: Can a stem cell-derived bioengineered ovarian model be developed that mimics the hormonal and reproductive functions of the human ovary?

Stem cells represent one of the most promising therapeutic innovations in reproductive medicine, demonstrating a unique ability to repair tissues and activate hormonal functions responsible for fertility in both men and women. Recent research focuses on how these cells, particularly mesenchymal stem cells, can enhance the production of reproductive hormones such as testosterone and estrogen, thereby improving the chances of conception.