Recent years have seen a significant increase in bone tissue injuries due to various factors, driving scientific research to develop innovative solutions such as bone tissue engineering as an effective alternative to compensate for tissue defects. Despite advances in traditional bone engineering methods, challenges remain related to biomaterials, cells, and biological factors. This has opened the door to new therapeutic approaches that rely on activating endogenous skeletal stem cells (SSCs) to regenerate bone directly at the injury site, eliminating the need for external cell transplantation.



